What are the ingredients of rabies vaccine? ——Analysis of hot topics on the Internet in the past 10 days
Recently, the ingredients of rabies vaccines and their safety have become hot topics on social platforms and health forums. With the increase in pet ownership and public attention on vaccine knowledge, many people want to know the specific ingredients of rabies vaccine and its mechanism of action. This article will combine the hot content of the entire Internet in the past 10 days to structurally analyze the composition of rabies vaccines, and attach relevant data comparisons.
1. Core components of rabies vaccine
The main components of rabies vaccine include inactivated virus, adjuvants, stabilizers and preservatives. The following is the specific classification and function description:
| Ingredient type | common substances | Function |
|---|---|---|
| inactivate virus | Rabies virus strains (such as PV strain, PM strain) | Stimulate the immune system to produce antibodies |
| Adjuvant | Aluminum hydroxide, aluminum phosphate | Enhance immune response |
| Stabilizer | sucrose, gelatin | Protective Vaccine Active Ingredients |
| preservative | Thimerosal (some vaccines contain trace amounts) | Prevent bacterial contamination |
2. Differences in ingredients among different vaccine brands
According to the discussion data of major health platforms in the past 10 days, the following is a comparison of the ingredients of common rabies vaccine brands at home and abroad:
| Vaccine brand | inactivated virus strain | Adjuvant type | Does it contain preservatives? |
|---|---|---|---|
| Domestic Wilbo | PV strain | aluminum hydroxide | no |
| Imported Ruibibol | PM strain | Aluminum phosphate | Trace Thimerosal |
| Domestic Chengda Suda | CTN-1 strain | No adjuvant (purified vaccine) | no |
3. Three hot issues of public concern
1.Vaccine safety controversy: Some users are concerned about the neurotoxicity of thimerosal, but the WHO points out that the trace residues in the vaccine are far below the safety threshold.
2.Causes of allergic reactions: Gelatin or antibiotic residues (such as neomycin) may cause allergies in a small number of people. It is necessary to inform the doctor of allergy history before vaccination.
3.Differences in immune effects: The adjuvant vaccine produces antibodies faster, but may cause local redness and swelling; the purified vaccine has fewer side effects but requires multiple vaccinations.
4. Expert advice and latest developments
The Chinese Center for Disease Control and Prevention emphasized in a recent popular science live broadcast:Rabies vaccine ingredients have undergone strict safety evaluation, fever or local pain are common after vaccination and are normal reactions. In addition, the newly developed third-generation human diploid cell vaccine (such as HDCV) uses animal protein-free culture technology and has become a hot spot in the high-end market.
The data in this article are synthesized from WHO technical reports, State Food and Drug Administration public information and Zhihu/Weibo hot discussion posts (statistical period: October 15-25, 2023). If you need vaccination, please refer to the vaccine instructions actually provided by the medical institution.
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